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  • In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

  • Titanium dioxide is a versatile mineral that is used in a wide variety of industries, from cosmetics to food production to paint and coatings. One of the key factors that determines the quality and performance of titanium dioxide is its buff percentage. Manufacturers play a crucial role in ensuring that this percentage is at an optimal level to meet the needs of their customers.


  • Overall, titanium dioxide plays a vital role in both industrial applications and environmental protection. With China leading the way in the production of high-purity titanium dioxide, the country is well-positioned to meet the growing demand for this essential mineral. By continuing to invest in research and development, China can further enhance its capabilities in titanium dioxide production and contribute to the advancement of global technological innovation.
  • Titanium Dioxide (TiO2), commonly known as titanium white, is a widely used pigment due to its exceptional brightness and high refractive index. Among the various crystalline forms of TiO2, the rutile type has garnered significant attention for its unique characteristics and extensive applications.
  • Inflammation of the intestines

  • In its statement to USA TODAY, the FDA maintained that, in all post-approvals for food additives, our scientists continue to review relevant new information to determine whether there are safety questions and whether the use of such substance is no longer safe under the Federal Food, Drug, and Cosmetic Act.